- Grant Amount – $5,000,000
- Deadline – March 25, 2025
- CLICK HERE TO APPLY
The Novo Nordisk Foundation (NNF), Wellcome, and the Gates Foundation (GF) are jointly launching a new $5,000,000 initiative, Gram-Negative Antibiotic Discovery Innovator (Gr-ADI), to drive innovation in early drug discovery for Gram-negative pathogens.
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This Grand Challenges RFP will identify and select the first projects within the consortium. The focus of this RFP will be on the discovery of antibiotics with broad spectrum activity against Enterobacteriaceae, using Klebsiella spp. as the pathogen to initiate a discovery program.
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The Challenge
- The ultimate objective of Gr-ADI will be to enable discovery of safe and simple first-line broad-spectrum drugs for syndromic management, through:
- Development of novel and emerging biological, chemical, and AI tools that could be applied broadly for antibiotic discovery to identify new antibiotic targets.
- Application of these innovative approaches to generate chemical starting points for project-based drug discovery.
- Fostering a collective mindset to address gaps in knowledge, solve problems, and manage a portfolio of targets and hits.
Funding Information
- Projects with a duration of up to three years and a maximum requested budget of $5,000,000 USD are eligible for funding.
Eligibility:
- This initiative is open to nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions.
- Only individuals who are applying through a legally recognized corporate entity are eligible.
- They particularly encourage applications from institutions based in LMICs and projects led by women and other groups that are historically underrepresented in the drug discovery field. All applications received will then be reviewed on their merits.
- Lead applicants must be able to demonstrate the experience needed to drive and lead a project and to deliver on the objectives.
- Applications can be from multi- and inter-disciplinary teams, and they encourage lead applicants to put together diverse teams, promoting a diverse, inclusive, and supportive research environment.
- Researchers may participate as co-applicants or collaborators on multiple proposals but may submit only one application as a lead applicant to this RFP. If researchers are co-applicants or collaborators on multiple proposals, they must be able to demonstrate that they can dedicate enough time and resources to all projects if all the projects they are involved in are funded.
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